UPDATE (7/20/26): Major progress! The U.S. House of Representatives has passed its version of the FDA Modernization Act 3.0 (H.R. 2821). Although the Senate passed its own version of the bill in December 2025, both chambers must pass the same bill before it can become law. We have updated this letter campaign to once again urge U.S. senators to pass the FDA Modernization Act 3.0. If you previously signed or wrote to your representative, you can now write to your senators in support of this bill.
UPDATE (12/16/25): Victory! The United States Senate has passed the FDA Modernization Act 3.0 (S.355) by unanimous consent. We have updated our form so you can now send letters to members of the United States House of Representatives urging them to support this crucial bill as well.
UPDATE (3/14/25): We submitted 3,802 signatures to Acting FDA Commissioner Sara Brenner, calling on her to enforce the FDA Modernization Act 2.0 now. We have also updated this petition into a direct letter campaign urging U.S. senators to pass the FDA Modernization Act 3.0.
UPDATE (2/3/25): A bipartisan group of senators, led by Cory Booker (D-NJ), has introduced the FDA Modernization Act 3.0 (S.355) to ensure that the FDA will finally update its regulations and remove cruel and unnecessary animal testing mandates on new drugs.
Every year in the United States, around 25 million animals suffer and die in horrific and unnecessary laboratory experiments. The vast majority of these innocent dogs, primates, rabbits, mice, and other animals live their entire lives locked inside barren cages, waiting in fear to be taken out and subjected to unthinkable tortures before they are eventually killed in the name of research.
In December of 2022, a monumentally important bipartisan bill that should save millions of animals from the tragic fate of lab testing, the FDA Modernization Act 2.0, was passed by Congress as part of the 2023 federal omnibus appropriations bill and signed into law by President Biden.
The FDA Modernization Act 2.0 ended a federal mandate that experimental drugs must be tested on animals before they are used on humans in clinical trials, a requirement that had been in effect since 1938. The new law was designed to allow scientists to use safer, more reliable alternatives such as “tests conducted in vitro, in silico, or in chemico.” However, years later, the FDA has failed to update its regulations, and scientists who are currently submitting “Investigational New Drug (IND)” applications must still deal with FDA regulations that require animal trials.
The FDA Modernization Act 2.0 made animal trials optional, but by failing to update its forms, the FDA is essentially forcing scientists to continue testing on animals in violation of the 2022 law, despite the fact that 90-95% of drugs that pass animal tests eventually fail in human clinical trials, wasting billions of taxpayer dollars every year and precious time for patients.
This is unacceptable! The millions of animals languishing in testing labs for no reason deserve action now.
To address this problem, a bipartisan group of U.S. senators introduced the FDA Modernization Act 3.0 (S.355), which would force the FDA to finally update its regulations and end mandatory drug testing on animals once and for all.
If you live in the United States, please join Species Unite in calling on our lawmakers to pass the FDA Modernization Act 3.0 now.
If you don’t live in the United States, you can help raise awareness for this important bill by sharing this petition on social media.
